Just found this in iTunesU. Wow! You’ll recognize many of these names if you’re reading the tDCS literature. I’ve only watched the Michael Weisend talks (whom we met earlier on the blog) so far. I have a much better understanding of the difficulty of running a tDCS trial now. There’s a lot that can go wrong. If your protocols aren’t set up just right, your information might be useless. Here’s the web link iTunes Link from which you can download in iTunes. Downloads are quite slow.
Introduction to Neurosystems Engineering, Spring 2011 (ECE 595) Neurosystems Engineering is an emerging field at the intersection of Neuroscience, Psychology, and Engineering, and the University of New Mexico is its epicenter.
Course Intro Dr. Gerold Yonas
Course Syllabus Dr. Gerold Yonas
Tools and Techniques in Neuronal Stimulation Dr. Edl Schamiloglu
Basic Principles of Feedback and Control Prof. Chaouki T. Abdallah
Discussing the Course General Approach and Direction Dr. Gerold Yonas
Effects of Direct Current, Non-Invasive Brain Stimulation on Learning Michael Weisend
In the Laboratory Transcranial Direct Current Stimulation (tDCS) Michael Weisend
Posttraumatic Stress Disorder: Roles for Treatment & Prevention (Part I) Dr. Pilar M Sanjuan
Posttraumatic Stress Disorder Roles for Treatment & Prevention (Part II) Dr. Pilar M Sanjuan
Tour of the Mind Research Network Dr. Vince D. Calhoun
Neuroimaging of Intelligence and Creativity (Part I) Dr. Rex E. Jung
Neuroimaging of Intelligence and Creativity (Part II) Dr. Rex E. Jung
Memories and Migraines: Application of tDCS Laura Matzen
Neurochemistry Application in NonInvasive Brain Stimulation Dr. Charles Gasparovic
Non-Invasive Brain Stimulation 1:03:47 Lucas C. Parra
Epilepsy, Autism, and Novel Treatment Strategies Dr. Jeffrey David Lewine
The Emerging Field of Sleep Disorders Medicine Dr. Barry Krakow
Presentation of Class Projects Student
Hard to imagine how he’d have learned enough about tDCS to build a device, but have gotten the (typical) montage so wrong. Placing the cathode over left DLPFC and anode over right orbital is exactly the opposite of what you’ll find in most studies related to both depression and working memory. He doesn’t go into how he’s constructed his electrodes at all. Anecdotally, it is interesting that the reverse montage made him feel angry and depressed.
Some very excellent tDCS-related documents came to my attention over the weekend. I’m pretty sure I’d looked for at least one of them before, but that it was behind a paywall. I’ll provide links to the pdfs here, but suggest that (as has happened elsewhere on the blog) pdf links frequently go bad so ‘get em while they’re hot’.
…we applied cathodal tDCS (1.6mA) at the left anterior temporal lobe (ATL) together with anodal tDCS at the right ATL for approximately 10 min… None of the 22 participants in the main experiment solved the nine-dot problem before stimulation. But with 10 min of right lat- eralizing transcranial direct current stimulation (tDCS), we found that more than 40% of participants could do so.
Dr. Brent Williams, at his SpeakWisdom blog, published another excellent tDCS post updating his DIY device, and adding a .doc that outlines his recommended (For Discussion) protocols for depression, ‘Savant Learning’, memorization, and chronic pain.
His protocol describes directions for use with either his ‘User-Built tDCS Research Device’, or the ActivaDose II.
tRNS consists of the application of a random electrical oscillation spectrum over the cortex. tRNS can be applied at different frequency band ranges over the entire spectrum from 0.1 to 640 Hz…They applied tRNS to the visual cortices of healthy subjects and observed a significant improvement in the performance of healthy subjects in a visual perceptual learning task. This improvement was significantly higher than the improvement obtained with anodal tDCS…
And that folks, is how a weekend disappears down the rabbit hole!
Marom Bikson is CEO of Soterix Medical and Associate Professor at City College of New York in the Department of Biomedical Engineering. Marom is a distinguished tDCS scientist and prominent in the development of HD-tDCS. Download the interviewhere (zipped mp3). (Firefox users- there is an audio player here, but it’s displaying intermittently. Trying to track down the issue. In the meantime you can download the episode or open the page in another browser).
(We got a good forty minutes of interview in before the Skype gremlins caught up with us. I had to cobble an ending together.)
Perhaps depression studies are closest to FDA qualification for tDCS?
(Prediction is very hard, especially about the future – Yogi Berra.)
A device (NorDoc Smartstim) that can go to 4mA is being used in a smoking cessation trial? (Trial info indicates 2mA current dose.)
FDA tDCS approval would be device-specific at first. But would open the door to ‘me too’ mechanism, FDA 510(k)
HD tDCS can have multiple cathodes and or multiple anodes. An array of 4 small anodes splitting 2mA, for example (.5 mA each electrode), can function as an anodal ‘virtual pad’. Assumes cathode somewhere else on the body).
Image By Richard McKinley USAF
Tolerability is how tolerable in terms of side effects a medication is.
A Theory of tDCS (“Gross oversimplification”) As positive current flows into the cortex it passes neurons.
Because of the nature of neurons, this positive current depolarizes somas (cell’s body), increasing excitability, thereby increasing the functionality & plasticity of that region (hypothesis… “We really don’t know.”). Under the cathode, somas (cells) are being hyper-polarized – excitabilty decreases.
A synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another cell. Pyramidal neuron
Titration, also known as titrimetry, is a common laboratory method of quantitative chemical analysis that is used to determine the unknown concentration of an identified analyte.
TES Transcranial Electric Stimulation
“transcranial electrical stimulation” Merton and Morton 1980
“Priming the network in conjunction with applying tDCS makes a lot of sense, as a way to make the tDCS to do what you want.” (Co-priming – The idea that one would initiate an activity first, and THEN add tDCS.)