Gamma Waves Enhance the Brain’s Immune System to Treat Mice with Alzheimer’s disease. v2 40hz tACS

I was first alerted to the story from a December 7 article in the Guardian, “Strobe lighting provides a flicker of hope in the fight against Alzheimer’s“. Researchers from the Picower Institute for Learning and Memory at MIT, working with (let’s call them) ‘Alzehiemer’s mice’, had discovered that flashing a light at 40hz (on-off at 40 times per second) increased gamma wave oscillations in the brain which led to the reduction of Amyloid beta (think, plaque) through the activation of microglia ‘clean-up’ immune cells. Here, let them explain it!

The paper, Gamma frequency entrainment attenuates amyloid load and modifies microglia makes clear that the light-flickering affected the visual cortex, which makes sense, as the light reaches the brain through the eyes. But wait, thinks I, what about tACS (transcranial Alternating Current Stimulation)… haven’t I seen numerous papers implying the ability to ‘entrain’ brain waves with tACS? What if you could increase 40hz Gamma in other parts of the brain? (Google Scholar Search: transcranial alternating, entrain, gamma)
But then I discovered that Radiolab just covered this exact story and it’s totally amazing! Really a must listen. So fun to hear the researcher’s amazement at this accidental (sort of) discovery!
So what’s with the photo of the v2 device set up for a 40hz tACS session? Just that…

More about The Picower Institute for Learning and Memory at MIT

Do You Use Scientific Papers To Inform Your Home tDCS Use? Take The Survey!

Hi John, our research centre (CIBF via The Brain Dialogue) is doing a project involving home users of brain stimulation, the details of which can be found here We’re currently conducting a survey on how these home users find and use scientific literature. If it’s appropriate for your website, we would love if you could post about the survey as we want a broad range of home users to participate and DIYtDCS keeps cropping up in the conversations we have about home use. The survey can be found here Please let me know if you have any questions or want more info about the project; you can also reach me via Twitter @ElizabethJPaton

A little more about The Brain Dialogue.

Medical Batteries – The History of Electrotherapy

Update 2/17/17 BBC The strange Victorian fashion of self-electrification

If you’ve been following along very closely you may recall that podcast episode #6 guest Anna Wexler mentioned in passing that she had been researching Ye Olde practice of therapeutically applying current to various parts of the body. Well, an early version of a new paper of hers landed the other day: Recurrent themes in the history of the home use of electrical stimulation: Transcranial direct current stimulation (tDCS) and the medical battery (1870–1920). It’s behind a paywall but here are some highlights.

  • Although the home use of tDCS is often referred to as a novel phenomenon, in reality the late nineteenth and early twentieth century saw a proliferation of electrical stimulation devices for home use.
  • In particular, the use of a portable electrotherapy device known as the “medical battery” bears a number of striking similarities to the modern-day use of tDCS.
  • Many features related to the home use tDCS—a do-it-yourself movement, anti-medical establishment themes, conflicts between lay and professional usage—are a repetition of themes that occurred a century ago with regard to the medical battery.
  • A number of features seem to be unique to the present, such as the dominant discourse about risk and safety, the division between cranial and non-cranial stimulation, and utilization for cognitive enhancement purposes.
  • Viewed in historical context, the contemporary use of electrical stimulation at home is not unusual, but rather the latest wave in a series of ongoing attempts by lay individuals to utilize electricity for therapeutic purposes.

Lots of ‘medical battery’ patents here.
And a ton of wonderful images to be found in books in Google’s digitized library.
Most of these came from a single book!