Frontiers | A Randomized Double-Blind Sham-Controlled Study of Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression

Reversing (usual) placement of electrodes in a treatment-resistant major depression (TRD) study resulted in no apparent effect.

Side effects did not differ between the two groups and in general the treatment was very well tolerated.
Conclusion: Anodal stimulation to the left DLPFC and cathodal stimulation to the right DLPFC was not efficacious in TRD. However, a number of methodological limitations warrant caution in generalizing from this study.

via Frontiers | A Randomized Double-Blind Sham-Controlled Study of Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression | Frontiers in Neuropsychiatric Imaging and Stimulation.

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