DIY tDCS Start Here

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New to DIYtDCS? This is the ‘start here’ collection of articles and posts.

  1. DIYtDCS Feed, last 50 articles https://www.diytdcs.com/feed/
  2. My Twitter feed focuses on breaking tDCS research. @DIYtDCS
  3. My Reddit account, where it’s okay to explore the fringes. DIYtDCS
  4. Recommended device? (29V / 2mA model. Promo code ‘diytdcs’ for discount)
  5. Best instruction video for C3/Motorcortex & F3/DLPFC electrode placement.
  6. Is this (tDCS for depression in pregnancy) the first ‘killer app’?
  7. Cognitive Enhancement with Noninvasive Brain Stimulation (video) Roy Hamilton MD
  8. Simple Montage list with electrode placement and research sources.
  9. Marom Bikson & Peter Toshev ‘Your Electric Pharmacy‘ (excellent overview/intro).
  10. My podcast interviews – deep dives into tDCS with key players (iTunes link)
  11. tDCS SubReddit is where the action is. Now with tDCS FAQ!
  12. Dr. Brent Williams’ DIY device and protocol.
  13. Zap your brain into the zone: Fast track to pure focus
  14. Better Living Through Electrochemistry
  15. Clinical tDCS trials seek volunteers. All. Search. (Example: “tDCS AND Los Angeles”)
  16. Neuroscience: Brain buzz Nature Magazine
  17. DLPFC / F3 Locator (you’ll need a tape measure with Centimeters)
  18. Foc.us 3d tDCS Placements Guide Model
  19. Searchable database of tDCS articles from trans-cranial.com
  20. 10–20 international system
  21. Kadosh The Stimulated Brain: Cognitive Enhancement Using NIBS

HD tACS to Synchronize Medial Frontal Cortex & Lateral Prefrontal Cortex Leads to Improved Executive Function

[Update 4/19] Reinhart Lab has a new paper out that is going to attract a lot of attention. Using HD-tACS, they were able to improve Working Memory in older adults (compared to younger adults). This article nicely summarizes the experiment: Brainwave Synchronization Reverses Age-related Decline in Working Memory …HD-tACS boosted interactions between theta & gamma rhythms in left temporal cortex & synchronization of theta brainwaves between left temporal cortex and prefrontal cortex. Paper: Working memory revived in older adults by synchronizing rhythmic brain circuits.


You may have noticed that I’ve not been posting as much to the blog lately. The blog is already so full of useful content for anyone looking into tDCS that I’m inclined to only post significant information that would move our current understanding of tDCS and neurostimulation forward. This article/paper describing a new technique using ‘HD tACS’ to synchronize (brainwaves) parts of the brain definitely looks intriguing and has implications for anyone paying attention to DIY neurostimulation. Very early, but very interesting.

Prof Rob Reinhart. Photo by Cydney Scott for Boston University Photography

Full story:  “Turbo Charge” for Your Brain? by By Barbara Moran

“These (medial frontal cortex & lateral prefrontal cortex) are maybe the two most fundamental brain areas involved with executive function and self-control,” says Reinhart, who used a new technique called high-definition transcranial alternating current stimulation (HD-tACS) to stimulate these two regions with electrodes placed on a participant’s scalp. Using this new technology, he found that improving the synchronization of brain waves, or oscillations, between these two regions enhanced their communication with each other, allowing participants to perform better on laboratory tasks related to learning and self-control. Conversely, de-synchronizing or disrupting the timing of the brain waves in these regions impaired participants’ ability to learn and control their behavior, an effect that Reinhart could quickly fix by changing how he delivered the electrical stimulation. The work, published October 9, 2017, in the journal Proceedings of the National Academy of Sciences (PNAS), suggests that electrical stimulation can quickly—and reversibly—increase or decrease executive function in healthy people and change their behavior.

Here’s the paper (paywall): Disruption and rescue of interareal theta phase coupling and adaptive behavior. The supplemental pdf. describes the equipment used in the experiment.
High definition transcranial alternating current stimulation ( HD- tACS ). The alternating current stimulation was administered noninvasively using an MxN9-3 channel high definition transcranial electrical current stimulator from Soterix Medical (New York, NY). Eight sintered Ag/AgCl electrodes were attached to high-definition plastic holders, filled with conductive gel, and embedded in the Biosemi EEG cap. HD-tACS electrode placement was guided by current-flow modeling using HD- Explore and HD-Targets (Soterix Medical), with the goal of targeting the MFC and lPFC to facilitate the synchronization of neural activity between these regions (the in phase protocol ) or disrupt the signals being conveyed between the MFC and lPFC (the antiphase protocol ).

Listen to Bob McDonald discuss HD tACS with Prof Rob Reinhart on the always interesting Quirks and Quarks.

Gamma Waves Enhance the Brain’s Immune System to Treat Mice with Alzheimer’s disease.

Foc.us v2 40hz tACS

[Update 3/18/19] Exciting news in the fight against Alzheimer’s!
Dr. Tsai has a new lab. Tsai Laboratory

In the new study, researchers added acoustic stimulation that pulsed at the same frequency as the visual stimulation. And when mice — which were bred to develop Alzheimer’s-like symptoms — were exposed to both, researchers saw that the neurons in several of their brains’ key memory circuits chimed in and began humming along at exactly the same frequency.
What came next was remarkable and unexpected, even to the authors of the study.
In the wake of the sound and light sessions, an army of newly energized immune cells descended on several areas of the treated brains, including those most affected by dementia. Then they set to work with a vengeance on some neglected housecleaning.

LA Times https://www.latimes.com/science/sciencenow/la-sci-sn-alzheimers-brain-waves-20190315-story.html
Auditory stimulation combined with light-induced gamma oscillations in the hippocampus CA1 and auditory cortex regions of the brain reduces amyloid levels and improves memory in animal models of Alzheimer’s disease.
What does 40 Hz sound like? via NYT

A Possible Alzheimer’s Treatment With Clicks and Flashes? It Worked on Mice (NYT)
Light and sound stimulus therapy generates a buzz in Alzheimer’s research world (LAT)

——–
[Update 2/3/18] Nature reports on updates since the information about the research first emerged. How flashing lights and pink noise might banish Alzheimer’s, improve memory and more
——— Original article
I was first alerted to the story from a December 7 article in the Guardian, “Strobe lighting provides a flicker of hope in the fight against Alzheimer’s“. Researchers from the Picower Institute for Learning and Memory at MIT, working with (let’s call them) ‘Alzehiemer’s mice’, had discovered that flashing a light at 40hz (on-off at 40 times per second) increased gamma wave oscillations in the brain which led to the reduction of Amyloid beta (think, plaque) through the activation of microglia ‘clean-up’ immune cells. Here, let them explain it!


The paper, Gamma frequency entrainment attenuates amyloid load and modifies microglia makes clear that the light-flickering affected the visual cortex, which makes sense, as the light reaches the brain through the eyes. But wait, thinks I, what about tACS (transcranial Alternating Current Stimulation)… haven’t I seen numerous papers implying the ability to ‘entrain’ brain waves with tACS? What if you could increase 40hz Gamma in other parts of the brain? (Google Scholar Search: transcranial alternating, entrain, gamma)
But then I discovered that Radiolab just covered this exact story and it’s totally amazing! Really a must listen. So fun to hear the researcher’s amazement at this accidental (sort of) discovery!
So what’s with the photo of the Foc.us v2 device set up for a 40hz tACS session? Just that…

More about The Picower Institute for Learning and Memory at MIT

Unboxing of the Activadose II tDCS Device with Caputron Starter Kit.

This video shows what is included with the Activadose tDCS Starter Kit from Caputron as well as a quick start guide. For more in depth look at how to use the device or to purchase this device, visit Caputron.com (As mentioned elsewhere on the blog, I have an affiliate relationship with Caputron. If you purchase any product from Caputron using code diytdcs at checkout, you will receive a discount and I will receive an affiliate fee.)

Halo: A headset that makes you learn faster | Should This Exist? (Podcast)

Neuroscientist Daniel Chao created a headset that hacks your brain with electricity so you can learn as fast as a kid again. It’s called Halo, and it helps you learn motor skills faster. Athletes use it; musicians too. But we’re not far from a future when Halo could help anyone master anything. Where will that take us? Host Caterina Fake leads the journey, joined by Comedian Baratunde Thurston and Quartz Editor in Chief Kevin Delaney, who help Daniel future-cast, and see his invention through the future best for humanity.

Physical Medicine and Rehabilitation Non-Invasive Brain Stimulation (NIBS) | John Hopkins

Michael was told he had reached his limit on what he could do. This was not something Michael and his partner, Jason, would accept. They began to look for other options and found Johns Hopkins Physical Medicine and Rehabilitation’s Non-Invasive Brain Stimulation (NIBS) as Michael’s answer to improve. Watch to learn more about Pablo Celnik and his team’s approach to setting Michael on a path to recovery.

John Hopkins Physical Medicine and Rehabilitation

Doc Johnson’s DIY Build | diligent5.org

From a comment to the blog. Doc Johnson shares this beautiful DIY tDCS build. Thanks Doc!

TDCS Controller Step 4 – Redesign

I’m personally just beginning experimenting with TDCS, and as an avid DIYer, I built my own. The open designs I’ve seen seem to be a little short on features (particularly a fail-safe over-current protection), so I decided to use my background as an Electrical Engineer to start from scratch. It might be useful for others who are interested in building their own.

The design incorporates a feature that trips something equivalent to a circuit breaker if more than about 4.8mA of current flows through the electrodes. It should never happen based on the current regulator design, but I’ve seen too many pieces of silicon short out in a way that would be dangerous in this situation. I finished testing the design this weekend, and am quite happy with it. All told, the parts are about $20, not counting the hours spent designing, building, testing, redesigning…

The design and links for how I built the circuit board are located at https://www.diligent5.org/?p=1993 I built it using surface mount components because I like the tighter resistor tolerances available, but theoretically the components (or something equivalent) are available as through-hole components for the less adventurous. Cheers, Doc Johnson

TDCS Controller Step 5 – Making Electrodes

tDCS and Parkinson’s

First of all I need to reiterate that I am not a health professional by any means (I’m a retired musician). I was attracted to tDCS when cognitive enhancement effects were first reported back in 2012. Now years later I’m still not convinced there’s anything more than placebo going on with tDCS as far as cognitive enhancement goes, though as I’ve stated elsewhere on the blog, the research seems more conclusive around tDCS being an effective treatment for depression.

Parkinson’s is a progressive, debilitating, and at present, incurable disease that robs people of a wide variety of function, but especially movement and speech-related abilities. I have a close friend with Parkinson’s so I’ve been following the related tDCS literature. A recent study suggests that tDCS may prove to be an effective way to help with movement issues.

In Effects of Transcranial Direct Current Stimulation (tDCS) Over the Frontal Polar Area on Motor and Executive Functions in Parkinson’s Disease; A Pilot Study researchers at Toyama University Hospital, Japan, found that anodal tDCS improved motor function in patients with Parkinson’s. Note that this was a very small study (9 patients, early in their Parkinson’s). In this blog post I will attempt to present a DIY version of the study protocol.

To the best of our knowledge, this is the first clinical research reporting that tDCS over the FPA successfully improved the motor and non-motor functions in PD patients. These findings suggest that tDCS over the FPA might be a useful alternative for the treatment of PD patients.

The first thing I noticed was that the montage (where to put the electrodes), “tDCS over the frontal polar area (FPA)” was unusual, therefore not easily verified by looking at other studies. The researchers had previously determined that stimulation of the FPA in healthy subjects improved hand dexterity (Cerebral functional imaging using near-infrared spectroscopy during repeated performances of motor rehabilitation tasks tested on healthy subjects). From the paper (my edits, for brevity and clarity in regards my purpose here)…

The stimulation current was delivered … through a pair of saline-soaked sponge electrodes (5 × 7 cm) over the frontal polar area FPA, and occipital area (OPA).
tDCS was applied for 1 week (5 times/week: Monday–Friday).
A constant current of 1.0 mA was delivered for 900 seconds (15 minutes).
During the tDCS protocol, the patients received traditional physical therapy in the upper extremities (stretching and muscle strength exercise) while sitting in a chair.

According to the 10-20 EEG system (pdf), FPA is defined as Fp1 and Fp2, and OPA is positioned near O1 and O2. Digging into the previous study I determined that they used FPZ to target FPA, and OZ to target OPA.

Yes but… what does that look like on a head? Here I’m indicating the electrode targets using the Foc.us placements head model.


(Above) Anode placed at Fpz to target the frontal polar area (FPA)


(Above) Cathode placed at Oz to target occipital area (OPA).

So basically, there you have it…
1 mA stimulation, (approx) 2″ x 2″ saline-soaked sponges, for 15 minutes placed at Anode-Fpz and Cathode-Oz, every day for five days. Note that the study participants underwent their usual regimen of physical therapy while the tDCS was being applied.

Am I suggesting you try this? No, I’m not.
I personally do intend to see if this can help my friend whose walking and talking are becoming difficult. For this reason I wanted to be as clear in my understanding of the study as possible.

Caputron Specials

These come up once in a while and I like to alert readers to Caputron specials. I’ll remove the post when I see that the special has ended. Remember to add discount code diytdcs at checkout for additional savings ( I also receive an affiliate fee when you use my discount code).

Stimulation Excites the Brain to Form Better Memories | NorthwesternU

Not tDCS, but TMS -Transcranial Magnetic Stimulation, another form of TES – Transcranial Electric Stimulation, that is being used both clinically (FDA approved for the treatment of depression) and as a research tool. Unlike tDCS, TMS can be of sufficient power to cause neurons to fire– imagine a finger twitching in response the the activation of the TMS device.

The video describes an experiment where researchers are attempting to improve the quality of memory encoding using TMS. The point of sharing it with you on the blog is to point out how difficult this is in fact to do. tDCS for cognitive enhancement was what initially inspired this blog, and now these six years later, I’m not sure we’re any closer to having a useful tool for cognitive enhancement of any kind, though I am reasonably confident in stating that tDCS for the treatment of depression is at least worth trying. (Other areas of research I’m more optimistic about are tDCS and Aphasia, tDCS and Parkinson’s, and tDCS for the enhancement of physical training. But in all of these the jury is still out, as there is conflicting research results.)

Note as well in the video the elaborate set up for measuring the effect of TMS in the memory study. These are often standardized tests used throughout psychology research. Unfortunately they are often costly and complicated to use. Point being that any sort of DIY cognitive enhancement experiments need to consider how effects will be measured.

Read more about the research here: Stimulation excites the brain to form better memories
Find the paper here: Selective and coherent activity increases due to stimulation indicate functional distinctions between episodic memory networks
See also: Hippocampal memory encoding and retrieval

Depression treatment technique uses new helmet therapy | BBC News

Updated 9/3/18: TMSuino3 A low-cost arduino-based TMS (transcranial magnetic stimulation) device.

This github project is a step-by-step manual. Anyone with a high school diploma should be able to follow it and build a TMSuino themselves. That’s what I was aiming for. TMSuino’s principle of operation is taken from a scientific paper published in the 1990s. So it is free of valid patent claims. Costs for parts, materials and shipping should be around 150,- dollars/euros. There is no soldering required! Estimated build time is 2 1/2 hours.

A comment on the blog from Martin Mueller informed me of this very interesting new arduino-based TMS device. I’ve also posted a link to the r/diytdcs Reddit page in hopes of hearing feedback from more technically-minded folks. I will update this post as info emerges. TMSuino3 seems to be loosely based on the work of Steen Dissing whose device we looked at in 2015 (see below) where it’s referred to as Transcranial Pulsating Electro Magnetic Fields therapy or t-PEMF.

The Introduction to the github article collects the author’s frustrations and suspicions around transparency in the bipolar research community and basically comes away from the experience hypothesizing what sounds like a conspiracy. Wait, big pharma and medical device companies manipulating the market to ensure maximum profit? Either way, he shares an article that confirms Steen Dissing’s frustration in getting his device accepted and adopted for treatment of depression in Denmark. An Inventor’s Triumph and Frustration.

It turns out a medical grade device has been developed and approved for treatment of depression in Denmark. The Re5, made by Navamedic. There are a collection of research papers linked to at their site.
————————– Original 2015 article.
Thanks to reader Jerico for alerting me to this. Transcranial Pulsating Electro Magnetic Fields therapy is new to me. It does not seem to be experiencing anywhere near the level of research activity that is going on around tDCS. Some of the research I’m finding dates from 2001 (though the BBC article the quote is from and linked to below is from 2014).  But just to have it on our radar, and because the helmet looks so cool…

“The helmet is amazing,” said Annemette Ovlisen, a graphic artist who suffered recurrent depression for 16 years and a participant in the Hillerod trials.
It’s like the fog lifts. It was like somebody hit the reset button.”The device contains seven coils that deliver a dose of Transcranial Pulsating Electro Magnetic Fields (T-PEMF) to brain tissues.The pulses are so minute that the patient cannot detect any sensation, and the only side effect so far is occasional “tiny” nausea that immediately disappears after treatment.
Prof Steen Dissing, of Copenhagen’s Faculty of Health Sciences is the helmet’s principal architect.
He said: “The device mimics electrical fields in the brain, and triggers the body’s own healing mechanism.”
The pulses activate capillaries in the brain, which form new blood vessels and secrete growth hormones.

PEMFhelmet

I’ts like somebody hit the reset button and I was back to normal.

PEMFhelmetDissingPEMFhelmetInUsevia BBC News – Depression treatment technique uses new helmet therapy.

Robin From Caputron Demonstrating Activadose II

Robin is the founder of Caputron which is a distributor of tDCS and other TES devices. Here he demonstrates the Activadose II tDCS device. For reasons mentioned elsewhere on the blog, this is the device I recommend (this is an FDA approved – for Iontophoresis – device. I’d suggest the 2mA model with the 3×3 sponge set – this is closest to what most research studies use). Caputron provides DIYtDCS readers a generous discount (I also earn a referral fee) when you use discount code ‘diytdcs’ at checkout (for any product offered by Caputron). I interviewed Robin back in 2015 when he was first getting started. Check out that post here.

Is e-meditation wave of the future? | MUSC News

This tweet, posted August 3, 2018, reminded me of Bashar W. Badran’s study (story below from 2017). Following along in the links I see that Badran has been testing a new ‘e-meditation’ device called Zendo. It’s currently not available to the general public, but you can see it in action in the photos below the tweet. You can sign up to be notified when the device becomes available here: https://e-meditation.com/about

Supercharge your zen (pdf) The benefits of yoga and meditation are plentiful, but they take years of dedicated practice to achieve. Could a zap to the brain offer a shortcut?

I had previously posted this in a comment. Sourced from the original study.

Each 20min E- meditation visit consisted of one of three randomized stimulation conditions (sham, active 1mA, or 2mA; anode – EEG F8, cathode – left supraorbital) delivered via a Chatanooga IontoTM stimulator and 2in x 2in sponge electrodes. Stimulation was synchronized with a guided mindfulness recording (recorded by ELG) lasting 20min.

Which is what’s depicted in the photo below.

Original article posted 2/12/17
Full article: Is e-meditation wave of the future?

Neuroscience doctoral student Bashar W. Badran is exploring the Use of tDCS to enhance Mindfulness Meditation (E-Meditation)
MUSC Research Assistant Caroline Summer is in background, demonstrating the tDCS device.
Photo by Sarah Pack

Badran, who used two different mindfulness scales and mood rating scales on 15 participants in a double-blind study, found that feelings of calmness increased almost 2.5 times in the group receiving active tDCS-paired meditation compared to the placebo. Individuals receiving the sham stimulation had just a 5 percent increase in calmness rating.

 

Paper (Paywall): A Double-Blind Study Exploring the Use of Transcranial Direct Current Stimulation (tDCS) to Potentially Enhance Mindfulness Meditation (E-Meditation)

New Caputron Bundles Including Focus V3

Update 8/2/18 Looks like the ActivaDose device special has ended but the Muse is still on sale. (If you’d like to receive an email when I notice special tDCS-related deals, please sign up for updates – in the sidebar.)
Update 7/25/18. I bumped this post to the top to alert readers to some very interesting deals Caputron is currently running. I will remove this when the specials end but at the moment you can purchase the ActivaDose Starter kit for $349, down from $399! Get an additional discount when you use discount code diytdcs at checkout! (At this time anyway, previously it’s been removed on specials.) They also have the Muse EEG headband on sale at $199, that’s $50 off. Not sure how long these specials will last. If you’ve been looking to acquire either of these devices here’s an opportunity to do so at a great price.

Robin at Caputron recently informed me of some new products they’re carrying including the Focus v3. The Focus v3 duplicates the functionality of the v2 (tRNS, tPCS, tACS and tDCS), but adds additional features such as what Focus calls ‘tRCS’, Transcranial Rippled Current Stimulation… as I understand it, a form of transcranial alternating current stimulation that targets multiple frequencies over time. tRCS is something new, invented by Focus, and therefore we have no scientific research to support its use at this time, but it looks very interesting. Considering the variety of stimulation modes the v3 supports, this is the obvious choice for anyone wanting to replicate research in the tACS and tRNS literature. Read more about the Focus v3 here: Instructions Guide.

Focus v3

Caputron is currently shipping the v3 with a variety of electrode options but the base unit is priced at $399. Use coupon code diytdcs at checkout for a generous discount on any product purchased from Caputron.

If you’re looking for a more ‘traditional’ type tDCS device, I recommend Caputron’s ActivaDose II tDCS Starter Kit. This is an FDA approved device (NOT for tDCS, but for iontophoresis, point being the electronics and manufacturing are at an FDA approved level). Note that the ActivaDose from Caputron comes as either an 80 Volt/4 mA Max unit, or a 29 Volt/2 mA Max. The cautious user would choose the 29 Volt model, as 2 mA is the maximum current used in most scientific studies. If you want a simple device your Mom could use, this is the way to go. Again, Use coupon code diytdcs at checkout for a generous discount.

Caputon is now carrying the Muse EEG device. They also carry more sophisticated research devices like those by Soterix. You can even purchase a TMS device through them. They have expert support and a great reputation.

 

 

Stimulating the Creative Brain – Morten Friis-Olivarius | PlatoScience

Stimulating the Creative Brain | Morten Friis-Olivarius | TEDxOslo
PlatoScience.com
PlatoWork neurostimulation device manual.

Shown here (from the video) working on the PlatoWork prototype. Note montage which according to the talk, would be focused on increasing creativity. In the video he calls the stimulation TES (Transcranial Electric Stimulation).

“Creative people somehow forget to turn off the spontaneous system while thye’re working on a task”.

A later prototype.

From the manual.

Aha, so there are 3 electrodes. And the placement resembles another study I’m aware of that used tACS to enhance creativity. (Functional role of frontal alpha oscillations in creativity). In that study…

Stimulation electrodes were positioned bilaterally over the frontal cortex (centered on EEG electrode locations F3 and F4) with a common electrodeover the apex (Cz).

But the PlatoScience FAQ clearly states they’re using tDCS.

At PlatoScience we use a version of neurostimulation called tDCS (Transcranial Direct Current Stimulation).

So here we have the first (to my knowledge) commercially available (€399) TES device designed specifically to enhance creativity. Interestingly, PlatoScience has a forum and test site (according to the video) where users can discuss their experience. The device is operated via smart phone.

Adam Gazzaley | Wisdom Labs Podcast

Source: WW009 – “Could Video Game Technology Solve the Global Cognition Crisis?” – with Adam Gazzaley, MD, PhD

Adam Gazzaley and Parneet Pal, Chief Science Officer of Wisdom Labs, discuss the challenges of the modern world for our ancient brains, how to become aware of, and overcome, the interference of distraction and multitasking, and the new era of digital medicine. Conversation includes: The critical elements of what it means to be human, ethical design of technology, the cascading effect of cognitive challenges, and harnessing neuroplasticity through experience to develop stronger brains…

The Distracted Mind: Ancient Brains in a High-Tech World by Adam Gazzaley (Amazon link)

Akili, the business end of Gazzaley’s research aims to build ‘experiential treatments’, delivered through video games, “…as medicine–as prescribable, reimbursable medicine, right up there with pharmaceuticals”. The patent is not for a video game, the patent is for a game engine… Akili now has a dozen studies going on across multiple clinical conditions. From Post Traumatic Stress Disorder to Traumatic Brain Injury to anxiety to Autism, depression, early Alzheimer’s Disease, Parkinson’s Disease, Multiple Sclerosis… The study which has garnered the most attention was the completion of our Phase 3 trial for Pediatric ADHD… What was shown was that we were able to significantly, with a reasonable effect size, improve attention ability in children with ADHD. Now advancing an application to the FDA for their class 2 medical device for the treatment of inattention in children with ADHD.

If we’re successful, it will be the first non-drug treatment for ADHD. The first prescribable video game, and the first of a new category of medicine that we think of as digital medicine, to treat a host of different conditions of the mind.