Category Archives: Clinical Trial

Experimental Brain Research, Volume 166, Number 1 – SpringerLink

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Our results indicate that only anodal stimulation of the left prefrontal cortex, but not cathodal stimulation of left DLPFC or anodal stimulation of M1, increases the accuracy of the task performance when compared to sham stimulation of the same area. This accuracy enhancement during active stimulation cannot be accounted for by slowed responses, as response times were not changed by stimulation. Our results indicate that left prefrontal anodal stimulation leads to an enhancement of working memory performance. Furthermore, this effect depends on the stimulation polarity and is specific to the site of stimulation. This result may be helpful to develop future interventions aiming at clinical benefits.

via Experimental Brain Research, Volume 166, Number 1 – SpringerLink.

Tinnitus Clinical Trial: Transcranial Direct Current Stimulation tDCS for the Treatment of Tinnitus

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This would be huge.

Detailed Clinical Trial Description
Subjective tinnitus is a distressing condition characterized by the sensation of sound or noise in the absence of internal or external stimuli. Research indicates that tinnitus may develop due to maladaptive plastic changes in the auditory cortex and limbic system. These changes can be targeted using safe and noninvasive brain stimulation techniques like transcranial direct current stimulation tDCS. TDCS alters the excitability of the cortex using a weak direct current and may lead to long-term plastic changes, making it a potential therapeutic tool for the treatment of tinnitus.
Transient improvements in tinnitus have been reported after inhibitory stimulation of the auditory cortex and after excitatory stimulation of the prefrontal cortex, however the effects of a combined stimulation paradigm remain unknown. We hypothesize that a cumulative effect will be observed following repeated sessions of tDCS by modulating both the excitability of the auditory cortex and prefrontal cortex.

via Tinnitus Clinical Trial: Transcranial Direct Current Stimulation tDCS for the Treatment of Tinnitus [Conditions: Tinnitus; Interventions: BrainSTIM Transcranial Stimulator, BrainSTIM Transcranial Stimulator].