Language and Memory Improvements following tDCS of Left Lateral Prefrontal Cortex | PLOS ONE

Using transcranial direct current stimulation, we tested whether stimulation of left lateral prefrontal cortex had discriminate effects on language and memory conditions that rely on executive-control (versus cases with minimal executive-control demands, even in the face of task difficulty). Participants were randomly assigned to receive Anodal, Cathodal, or Sham stimulation of left lateral prefrontal cortex while they (1) processed ambiguous and unambiguous sentences in a word-by-word self-paced reading task and (2) performed an n-back memory task that, on some trials, contained interference lure items reputed to require executive-control. Across both tasks, we parametrically manipulated executive-control demands and task difficulty. Our results revealed that the Anodal group outperformed the remaining groups on (1) the sentence processing conditions requiring executive-control, and (2) only the most complex n-back conditions, regardless of executive-control demands. Together, these findings add to the mounting evidence for the selective causal role of left lateral prefrontal cortex for executive-control tasks in the language domain. Moreover, we provide the first evidence suggesting that brain stimulation is a promising method to mitigate processing demands encountered during online sentence processing.

Source: PLOS ONE: Language and Memory Improvements following tDCS of Left Lateral Prefrontal Cortex

Weekend tDCS Insights – Chi & Snyder, SpeakWisdom, Carlo Miniussi

Some very excellent tDCS-related documents came to my attention over the weekend. I’m pretty sure I’d looked for at least one of them before, but that it was behind a paywall. I’ll provide links to the pdfs here, but suggest that (as has happened elsewhere on the blog) pdf links frequently go bad so ‘get em while they’re hot’.

Brain stimulation enables the solution of an inherently difficult problem (pdf)
This is the paper by Alan Snyder and Richard Chi that is frequently referenced in ‘unlock your inner savant’ articles on various pop-sci sites. (See also) Spoiler alert! Gives the answer to the ‘9 dot’ problem and once you’ve seen it it will be impossible to discover how ‘savant-like’ you are (at least according to this test).

ninedot …we applied cathodal tDCS (1.6mA) at the left anterior temporal lobe (ATL) together with anodal tDCS at the right ATL for approximately 10 min… None of the 22 participants in the main experiment solved the nine-dot problem before stimulation. But with 10 min of right lat- eralizing transcranial direct current stimulation (tDCS), we found that more than 40% of participants could do so.

speakWisdomTakeapartDr. Brent Williams, at his SpeakWisdom blog, published another excellent tDCS post updating his DIY device, and adding a .doc that outlines his recommended (For Discussion) protocols for depression, ‘Savant Learning’, memorization, and chronic pain.
His protocol describes directions for use with either his ‘User-Built tDCS Research Device’, or the ActivaDose II.

Transcranial Magnetic and Electric Stimulation in Perception and Cognition Research (pdf)
This is a fascinating paper (Carlo Miniussi et al) that brings us up to date (2012) on applications of tDCS, TMS tACS (transcranial alternating current), and tRNS (transcranial random noise stimulation), especially in relation to cognition and learning. What really caught my eye was this entry about tRNS…

 tRNS consists of the application of a random electrical oscillation spectrum over the cortex. tRNS can be applied at different frequency band ranges over the entire spectrum from 0.1 to 640 Hz…They applied tRNS to the visual cortices of healthy subjects and observed a significant improvement in the performance of healthy subjects in a visual perceptual learning task. This improvement was significantly higher than the improvement obtained with anodal tDCS…

And that folks, is how a weekend disappears down the rabbit hole!