Tyler Cowen interviews Ed Boyden of MIT in this excellent interview. (Seriously, listen to this interview).
Ed Boyden is a neuroscientist and his lab, Synthetic Neurobiology Group is serving up a steady stream of cutting edge brain research. Especially of interest to DIYtDCS viewers is his involvement in a new form of non-invasive brain stimulation able to reach deep into the brain…
The method, called temporal interference, involves beaming different electric frequencies, too high for neurons to respond to, from electrodes on the skull’s surface. The team found that where the currents intersected inside the brain, the frequencies interfered with each other, essentially canceling out all but the difference between them and leaving a low-frequency current that neurons in that location responded to, Dr. Boyden said.
[Update 3/18/19] Exciting news in the fight against Alzheimer’s! Dr. Tsai has a new lab. Tsai Laboratory
In the new study, researchers added acoustic stimulation that pulsed at the same frequency as the visual stimulation. And when mice — which were bred to develop Alzheimer’s-like symptoms — were exposed to both, researchers saw that the neurons in several of their brains’ key memory circuits chimed in and began humming along at exactly the same frequency. What came next was remarkable and unexpected, even to the authors of the study. In the wake of the sound and light sessions, an army of newly energized immune cells descended on several areas of the treated brains, including those most affected by dementia. Then they set to work with a vengeance on some neglected housecleaning.
LA Times https://www.latimes.com/science/sciencenow/la-sci-sn-alzheimers-brain-waves-20190315-story.html
The paper, Gamma frequency entrainment attenuates amyloid load and modifies microglia makes clear that the light-flickering affected the visual cortex, which makes sense, as the light reaches the brain through the eyes. But wait, thinks I, what about tACS (transcranial Alternating Current Stimulation)… haven’t I seen numerous papers implying the ability to ‘entrain’ brain waves with tACS? What if you could increase 40hz Gamma in other parts of the brain? (Google Scholar Search: transcranial alternating, entrain, gamma) But then I discovered that Radiolab just covered this exact story and it’s totally amazing! Really a must listen. So fun to hear the researcher’s amazement at this accidental (sort of) discovery! So what’s with the photo of the Foc.us v2 device set up for a 40hz tACS session? Just that…