Shown here (from the video) working on the PlatoWork prototype. Note montage which according to the talk, would be focused on increasing creativity. In the video he calls the stimulation TES (Transcranial Electric Stimulation).
“Creative people somehow forget to turn off the spontaneous system while thye’re working on a task”.
Stimulation electrodes were positioned bilaterally over the frontal cortex (centered on EEG electrode locations F3 and F4) with a common electrodeover the apex (Cz).
But the PlatoScience FAQ clearly states they’re using tDCS.
At PlatoScience we use a version of neurostimulation called tDCS (Transcranial Direct Current Stimulation).
So here we have the first (to my knowledge) commercially available (€399) TES device designed specifically to enhance creativity. Interestingly, PlatoScience has a forum and test site (according to the video) where users can discuss their experience. The device is operated via smart phone.
Adam Gazzaley and Parneet Pal, Chief Science Officer of Wisdom Labs, discuss the challenges of the modern world for our ancient brains, how to become aware of, and overcome, the interference of distraction and multitasking, and the new era of digital medicine. Conversation includes: The critical elements of what it means to be human, ethical design of technology, the cascading effect of cognitive challenges, and harnessing neuroplasticity through experience to develop stronger brains…
Akili,the business end of Gazzaley’s research aims to build ‘experiential treatments’, delivered through video games, “…as medicine–as prescribable, reimbursable medicine, right up there with pharmaceuticals”. The patent is not for a video game, the patent is for a game engine… Akili now has a dozen studies going on across multiple clinical conditions. From Post Traumatic Stress Disorder to Traumatic Brain Injury to anxiety to Autism, depression, early Alzheimer’s Disease, Parkinson’s Disease, Multiple Sclerosis… The study which has garnered the most attention was the completion of our Phase 3 trial for Pediatric ADHD… What was shown was that we were able to significantly, with a reasonable effect size, improve attention ability in children with ADHD. Now advancing an application to the FDA for their class 2 medical device for the treatment of inattention in children with ADHD.
If we’re successful, it will be the first non-drug treatment for ADHD. The first prescribable video game, and the first of a new category of medicine that we think of as digital medicine, to treat a host of different conditions of the mind.
Robin at Caputron recently informed me of some new products they’re carrying including the Focus v3. The Focus v3 duplicates the functionality of the v2 (tRNS, tPCS, tACS and tDCS), but adds additional features such as what Focus calls ‘tRCS’, Transcranial Rippled Current Stimulation… as I understand it, a form of transcranial alternating current stimulation that targets multiple frequencies over time. tRCS is something new, invented by Focus, and therefore we have no scientific research to support its use at this time, but it looks very interesting. Considering the variety of stimulation modes the v3 supports, this is the obvious choice for anyone wanting to replicate research in the tACS and tRNS literature. Read more about the Focus v3 here: Instructions Guide.
If you’re looking for a more ‘traditional’ type tDCS device, I recommend Caputron’s ActivaDose II tDCS Starter Kit. This is an FDA approved device (NOT for tDCS, but for iontophoresis, point being the electronics and manufacturing are at an FDA approved level). Note that the ActivaDose from Caputron comes as either an 80 Volt/4 mA Max unit, or a 29 Volt/2 mA Max. The cautious user would choose the 29 Volt model, as 2 mA is the maximum current used in most scientific studies. If you want a simple device your Mom could use, this is the way to go. Again, Use coupon code diytdcs at checkout for a generous discount.
Caputon is now carrying the Muse EEG device. They also carry more sophisticated research devices like those by Soterix. You can even purchase a TMS device through them. They have expert support and a great reputation.
The paper, Gamma frequency entrainment attenuates amyloid load and modifies microglia makes clear that the light-flickering affected the visual cortex, which makes sense, as the light reaches the brain through the eyes. But wait, thinks I, what about tACS (transcranial Alternating Current Stimulation)… haven’t I seen numerous papers implying the ability to ‘entrain’ brain waves with tACS? What if you could increase 40hz Gamma in other parts of the brain? (Google Scholar Search: transcranial alternating, entrain, gamma)
But then I discovered that Radiolab just covered this exact story and it’s totally amazing! Really a must listen. So fun to hear the researcher’s amazement at this accidental (sort of) discovery!
So what’s with the photo of the Foc.us v2 device set up for a 40hz tACS session? Just that…
More about The Picower Institute for Learning and Memory at MIT
It ‘makes sense’ that stimulating neurons in areas of the brain affected by Alzheimer’s would be of benefit, but as the researchers state, we won’t know for sure until the science is complete. In the meantime, if you know anyone in Montreal with Alzheimer’s issues, the study is recruiting.
The study is still accepting new patients.To find out more, contact researchers at the Research Institute of the MUHC at 514-934-1934 ext 34439 or Rishanthi.sivakumaran [@] rimuhc.ca
Little information accompanies this video, but it appears to me that Karly Chapman is an Aphasia clinician demonstrating tDCS setup for fellow clinicians. She sets up for an Anomia treatment. It strikes me that a motivated family member wouldn’t have much trouble replicating this at home. Also that an online version would be a useful tool for clinicians and patients alike.
Dr. Roy Hamilton of the University of Pennsylvania describes two types of noninvasive brain-stimulation technologies — transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) — and addresses their potential role in the assessment and treatment of FTD disorders. This webinar, presented on November 30, 2017, is the fifth in the AFTD Educational Webinar series.
We’ve met Adam Gazzaley elsewhere on the blog, but probably because he and Rob Reid have a friendship spanning years, this is a very friendly and thorough discussion of all Adam is up to. Reid has a new book (fiction, sci-fi) called After On, and Gazzaley was called on to provide insights into a few of the book’s key concepts related to consciousness and neuroscience.
There has been a lot of talk in the literature lately about tACS as it applies to cognitive enhancement and this is explored in the conversation. If I got this right… there is a distinct pattern of ‘Midline Frontal Theta’ frequency, at around 6Hz (as measured by EEG) associated with ‘focus’ (as measured by fMRI) in the Pre Frontal Cortex. This begs the question as to whether focus could be generated by using tACS to ‘entrain’ the PFC (as in… induce 6Hz Theta in the PFC using tACS). Again I will remind the reader that I am not a scientist!
Gazzaley also brings us up to speed on the clinical trial for FDA clearance of EVO, his video game/therapeutic that Akili has developed for kids with ADHD.
The episode is embedded here, but swing over to https://after-on.com/episodes/002 to read the show notes and to learn more about Rob Reid. He has a number of fascinating interviews with other guests in his podcast and brings a lot to the table himself considering a long career both as a technologist, investor and author.
You may have noticed that I’ve not been posting as much to the blog lately. The blog is already so full of useful content for anyone looking into tDCS that I’m inclined to only post significant information that would move our current understanding of tDCS and neurostimulation forward. This article/paper describing a new technique using ‘HD tACS’ to synchronize (brainwaves) parts of the brain definitely looks intriguing and has implications for anyone paying attention to DIY neurostimulation. Very early, but very interesting.
Prof Rob Reinhart. Photo by Cydney Scott for Boston University Photography
“These (medial frontal cortex & lateral prefrontal cortex) are maybe the two most fundamental brain areas involved with executive function and self-control,” says Reinhart, who used a new technique called high-definition transcranial alternating current stimulation (HD-tACS) to stimulate these two regions with electrodes placed on a participant’s scalp. Using this new technology, he found that improving the synchronization of brain waves, or oscillations, between these two regions enhanced their communication with each other, allowing participants to perform better on laboratory tasks related to learning and self-control. Conversely, de-synchronizing or disrupting the timing of the brain waves in these regions impaired participants’ ability to learn and control their behavior, an effect that Reinhart could quickly fix by changing how he delivered the electrical stimulation. The work, published October 9, 2017, in the journal Proceedings of the National Academy of Sciences (PNAS), suggests that electrical stimulation can quickly—and reversibly—increase or decrease executive function in healthy people and change their behavior.
Here’s the paper (paywall): Disruption and rescue of interareal theta phase coupling and adaptive behavior. The supplemental pdf. describes the equipment used in the experiment.
High definition transcranial alternating current stimulation ( HD- tACS ). The alternating current stimulation was administered noninvasively using an MxN9-3 channel high definition transcranial electrical current stimulator from Soterix Medical (New York, NY). Eight sintered Ag/AgCl electrodes were attached to high-definition plastic holders, filled with conductive gel, and embedded in the Biosemi EEG cap. HD-tACS electrode placement was guided by current-flow modeling using HD- Explore and HD-Targets (Soterix Medical), with the goal of targeting the MFC and lPFC to facilitate the synchronization of neural activity between these regions (the in phase protocol ) or disrupt the signals being conveyed between the MFC and lPFC (the antiphase protocol ).
Listen to Bob McDonald discuss HD tACS with Prof Rob Reinhart on the always interesting Quirks and Quarks.
In the spirit of fairness, I’m posting this musician’s experience of using the Halo Sport for guitar training. Unlike Mario and his piano experience, this fellow, TomboLP, ultimately found no added benefit, though in earlier videos (this is the part 5 of 5) he was excited by what he assumed were positive results.
This is the last video in my test of the Halo Sport. As I didn’t reach the goals I set for myself in the time allotted and feel that there were no gains that couldn’t be otherwise explained by practice, I have now returned the headset. Even though the product didn’t work out for me, I will say that the return process was very straightforward and hassle-free.