Adam Gazzaley and Parneet Pal, Chief Science Officer of Wisdom Labs, discuss the challenges of the modern world for our ancient brains, how to become aware of, and overcome, the interference of distraction and multitasking, and the new era of digital medicine. Conversation includes: The critical elements of what it means to be human, ethical design of technology, the cascading effect of cognitive challenges, and harnessing neuroplasticity through experience to develop stronger brains…
Akili, the business end of Gazzaley’s research aims to build ‘experiential treatments’, delivered through video games, “…as medicine–as prescribable, reimbursable medicine, right up there with pharmaceuticals”. The patent is not for a video game, the patent is for a game engine… Akili now has a dozen studies going on across multiple clinical conditions. From Post Traumatic Stress Disorder to Traumatic Brain Injury to anxiety to Autism, depression, early Alzheimer’s Disease, Parkinson’s Disease, Multiple Sclerosis… The study which has garnered the most attention was the completion of our Phase 3 trial for Pediatric ADHD… What was shown was that we were able to significantly, with a reasonable effect size, improve attention ability in children with ADHD. Now advancing an application to the FDA for their class 2 medical device for the treatment of inattention in children with ADHD.
If we’re successful, it will be the first non-drug treatment for ADHD. The first prescribable video game, and the first of a new category of medicine that we think of as digital medicine, to treat a host of different conditions of the mind.
It ‘makes sense’ that stimulating neurons in areas of the brain affected by Alzheimer’s would be of benefit, but as the researchers state, we won’t know for sure until the science is complete. In the meantime, if you know anyone in Montreal with Alzheimer’s issues, the study is recruiting.
The study is still accepting new patients.To find out more, contact researchers at the Research Institute of the MUHC at 514-934-1934 ext 34439 or Rishanthi.sivakumaran [@] rimuhc.ca
Little information accompanies this video, but it appears to me that Karly Chapman is an Aphasia clinician demonstrating tDCS setup for fellow clinicians. She sets up for an Anomia treatment. It strikes me that a motivated family member wouldn’t have much trouble replicating this at home. Also that an online version would be a useful tool for clinicians and patients alike.
Dr. Roy Hamilton of the University of Pennsylvania describes two types of noninvasive brain-stimulation technologies — transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) — and addresses their potential role in the assessment and treatment of FTD disorders. This webinar, presented on November 30, 2017, is the fifth in the AFTD Educational Webinar series.
We’ve met Adam Gazzaley elsewhere on the blog, but probably because he and Rob Reid have a friendship spanning years, this is a very friendly and thorough discussion of all Adam is up to. Reid has a new book (fiction, sci-fi) called After On, and Gazzaley was called on to provide insights into a few of the book’s key concepts related to consciousness and neuroscience.
There has been a lot of talk in the literature lately about tACS as it applies to cognitive enhancement and this is explored in the conversation. If I got this right… there is a distinct pattern of ‘Midline Frontal Theta’ frequency, at around 6Hz (as measured by EEG) associated with ‘focus’ (as measured by fMRI) in the Pre Frontal Cortex. This begs the question as to whether focus could be generated by using tACS to ‘entrain’ the PFC (as in… induce 6Hz Theta in the PFC using tACS). Again I will remind the reader that I am not a scientist!
Gazzaley also brings us up to speed on the clinical trial for FDA clearance of EVO, his video game/therapeutic that Akili has developed for kids with ADHD.
The episode is embedded here, but swing over to https://after-on.com/episodes/002 to read the show notes and to learn more about Rob Reid. He has a number of fascinating interviews with other guests in his podcast and brings a lot to the table himself considering a long career both as a technologist, investor and author.
In the spirit of fairness, I’m posting this musician’s experience of using the Halo Sport for guitar training. Unlike Mario and his piano experience, this fellow, TomboLP, ultimately found no added benefit, though in earlier videos (this is the part 5 of 5) he was excited by what he assumed were positive results.
This is the last video in my test of the Halo Sport. As I didn’t reach the goals I set for myself in the time allotted and feel that there were no gains that couldn’t be otherwise explained by practice, I have now returned the headset. Even though the product didn’t work out for me, I will say that the return process was very straightforward and hassle-free.
Robin at Caputron dropped me a note to let me know they are now carrying the Foc.us V2 device. Purchased alone, it does not include electrodes, but there is an option to add their ‘starter kit’ which includes the Caputron Universal Strap, Caputron Banana Adapter Cable for Focus Device, and Choice of 2×2 or 3×3 Electrodes. (Use diytdcs at checkout for generous discount). Foc.us V2 Device at Caputron.
If what attracted you to tDCS is all the news (and hype) around the possible benefits, cognitive and otherwise, that tDCS may provide, then I recommend the Foc.us V2 device. It’s had a thorough going over, and apart from the (then included) electrodes, proved to be an amazing piece of gear. tDCS, tACS, tRNS, tPCS in a single sub $300 unit with a software interface!
Banana Plug for Foc.us
Elsewhere on the blog I’ve stated that I recommend the ActivaDose ll device. This is an FDA approved device – it’s NOT FDA approved for tDCS – it’s approval is for use as an Iontophoresis device. The point is that the electronics and workmanship have attained an FDA level of approval. It’s simple and straightforward to use.
The only reason I haven’t recommended other tDCS devices on the market is because I’m not in a position to analyze the quality of their workmanship myself. I recommend the Activadose ll because people looking to experiment with tDCS for the treatment of depression can’t be assumed to have a toolset for determining the mechanical workmanship of an electrical device they’re going to be attaching to their heads! The Activadose ll, an FDA approved device, at least assures the buyer the device itself is of high quality. It’s also more likely to retain some resale value in the event someone decides later on to sell it.
I recommend the Foc.us V2 because of it’s variety of stimulation modes. Folks who are sophisticated enough about neurostimulation to be experimenting with cognitive enhancement would obviously benefit from having the option to test other forms of stimulation that frequently come up in the scientific literature.
When you use code diytdcs at checkout at Caputron you get a discount, and I get a small commission.
I do hope to understand this better. Is it just that he was so impressed with his own Halo Sport experience that he was motivated to tell the world about it? Is it that Mario is a YouTube content creator and knew this would be compelling content? I will update the post as I learn more.
And here is the video Mario made in November, 2016 where he describes the impact using Halo Sport had on his piano playing.
Hey Mario, If you’re reading this drop me a line, I’d like to talk to you.
Insurers are starting to cover TMS for depression (after determining that SSRIs or other medications aren’t working for the patient). A full course, 24-36 treatments, of TMS can cost well over $10k. Though this is purely conjecture on my part, one way tDCS might make it into the mainstream is as a method to ‘top up’ post-TMS treatment as effects begin to fade.
Published on Jun 19, 2017 | YouTubeUCLA
As the number of people suffering from depression rises, doctors are looking for new, more targeted ways to treat it. One approach used by doctors at UCLA and a handful of other centers nationwide is to beam magnetic pulses deep into patients’ brains, a therapy known as transcranial magnetic stimulation (TMS). The therapy is time-consuming, and only a few hospitals or clinics offer it, but its ability to work in a fundamentally different way from medications is also what makes it so promising for people not helped by drugs.
Wow! No less than Hank Green ( of the Vlog Brothers) covering tDCS on his SciShow Psych! He sounds a little skeptical! So we have that in common. I pretty much agree with Hank’s perspective, just a couple of thoughts I’d like to share.
Most companies (but not all) know better than to make claims about tDCS. They know they have to be careful making claims of benefits. So where you see a company making a claim, they are most likely basing the claim on legit science. But are the benefits replicable in your situation? Hank refers to the (science) literature as ‘messy’ and he’s right, with different labs coming to opposite conclusions using basically the same experiment protocols.
Hank characterizes the basic function of tDCS as being a training session for neurons. Over time, with repeated stimulation, those neurons will start to fire more. While this is a legitimate description of the approach some research takes, I think a better way to think of it is that tDCS makes it easier for neurons that are already inclined to fire, to do so. As in- you’re focused on a “Where’s Waldo” task, and with the proper stimulation, the task is easier to do, because the targeted neurons have less resistance to firing.