Mind machines – the promise and problems of cognitive enhancement devices

In this video Roi Cohen Kadosh (Professor of Cognitive Neuroscience at the University of Oxford) likens the use tDCS without a task and purpose, to an athlete taking steroids and not exercising. He discusses recent papers coming out of his lab and describes the research that resulted in this paper: Combining brain stimulation and video game to promote long-term transfer of learning and cognitive enhancement. Kadosh points out that while tDCS did enhance performance in a math challenge, it simultaneously had a negative impact on another. Following Kadosh, Dr Hannah Maslen discusses DIY and DTC tDCS in the context of regulation in the EU.

Those who received real tDCS performed significantly better in the game than the sham group, and showed transfer effects to working memory, a related but non-numerical cognitive domain. This transfer effect was absent in active and sham control groups. Furthermore, training gains were more pronounced amongst those with lower baseline cognitive abilities, suggesting the potential for reducing cognitive inequalities. All effects associated with real tDCS remained 2 months post-training. Our study demonstrates the potential benefit of this approach for long-term enhancement of human learning and cognition.

Catching Up With tDCS News

If you’re a Twitter person, follow along here: https://twitter.com/DIYtDCS where I cover more advanced tDCS-related news.

In new work Jonides in presenting at the CNS conference, he and colleagues have found that tDCS has a robust effect on working memory, with enhancements lasting over a course of months. “Previous research has been equivocal about whether tDCS enhances training, and there have been no long-term investigations of how long that training effect lasts,” Jonides says.

In the new study, 62 participants randomly received tDCS stimulation to either the right or left prefrontal cortex or received sham stimulation while performing a visuospatial working memory task. After 7 training sessions, those who received the tDCS stimulation had increased working memory capabilities, even several months after completing their training. They also found that those who receive stimulation on the right prefrontal cortex had selective ability to transfer the working memory to non-trained tasks.

I will definitely be following up on this one. Neuroscientists working to test brain training claims 4/5/16
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Here, we review the recent research that has explored the effects of tDCS on WM (working memory) in healthy young adults, older adults, and patient populations. We also discuss several recent meta-analyses that have examined the efficacy of tDCS as a WM intervention. While a majority of the papers reviewed suggest that tDCS can modulate WM, this effect is highly inconsistent. These seemingly conflicting results may be driven by differences in study design, tDCS protocol, or inter-individual differences.

Meta research paper looks years of tDCS working memory research. Interesting and useful, in the list of papers they cite they add (highlighted) the particular significance of that paper. Uncertainty and Promise: the Effects of Transcranial Direct Current Stimulation on Working Memory  4/5/16
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Those advantages appeal to the DIY users as well. On Reddit’s tDCS community, many anonymous users describe using the technique to treat mental disorders, including depression and anxiety. Alexander Mark is one of them. A 63-year-old Michigan resident, he says, “I am afflicted with Bipolar Disorder II, and learned about tDCS in an effort to find a way to relieve myself of the severe depression that often comes with the illness.” He began trying it when his medication proved ineffective (though that’s no longer the case), and he’s only had a single negative experience—when he misplaced an electrode. (He currently uses the Chattanooga Ionto iontophoresis system, which sells for about $700 through third-party merchants on Amazon.)

Article also discusses a Direct To Consumer tDCS device that didn’t do so well in their tests. The promise and peril of DIY electrical brain stimulation By Anna Denejkina 4/10/16
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I would argue that the fine tradition of self-experimentation can be harnessed, if structures are created that allow at-home users to contribute their experiences to a common store of knowledge. At present online sharing of tDCS experiences is haphazard, and is restricted to the more anarchic fringes of the internet. However, those communities are generating potentially valuable information, which could be of great interest to researchers and to manufacturers. At-home and DIY users frequently stretch the limits of protocols, delivering higher current for greater amounts of time.17 Bringing at-home users into the fold will provide useful information about safe and unsafe protocols, and will generate important information about the milder side-effects of tDCS that are thought to be under-reported by researchers

In his paper The regulation of consumer tDCS: engaging a community of creative self-experimenters, Nick Davis makes the case that there is the potential for home-use DIY users to contribute to our understanding of tDCS. 4/5/16
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Tyler, who co-founded Thync and recently returned to academia as an associate professor at Arizona State University, says such concerns are legitimate. Yet he is certain that they can be overcome and that medical-grade brain devices will one day be commonplace and able to, for example, relieve the pain of migraines or treat debilitating neurological conditions.

“Yes, a lot more work still needs to be done,” he said. “But the technology holds tremendous promise. It’s not just about us saying we’re going to stimulate the nerves so you can chill.”

Mostly about the Thync (not tDCS) device. Note that Jamie Tyler, who was a co-founder and lead scientist at Thync, has returned to academia (and I’ll hazard a guess, to his first love, transcranial pulsed ultrasound stimulation). Brain-zapping gadgets promise to make you a better you — smarter, stronger, even happier. 3/29/16
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Understanding The Mechanism Underlying The Effects of tDCS

The paper, Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain, is being lauded as a major discovery among tDCS researchers. It is however, extremely hard to follow. Fortunately RIKEN also issued a press release describing the study in a way most tDCS-curious will understand. Read the full press release here.

Researchers at the RIKEN Brain Science Institute in Japan have discovered that the benefits of stimulating the brain with direct current come from its effects on astrocytes — not neurons — in the mouse brain. Published in Nature Communications, the work shows that applying direct current to the head releases synchronized waves of calcium from astrocytes that can reduce depressive symptoms and lead to a general increase in neural plasticity — the ability of neuronal connections to change when we try to learn or form memories.


(top) Low spontaneous calcium activity in a normal mouse followed by tDCS-induced calcium surges. (bottom) tDCS-induced calcium surges are absent in IP3 Receptor 2 knockout mice, indicating that the calcium surges originate in astrocytes, not neurons.
Note: The upper. ‘normal’ mouse brain vs. modified mouse brain, bottom. Watch near ticking clock when ‘spontaneous’ switches to ‘tDCS’.

Let’s put this in some context by having a quick look at astrocytes and glial cells. From 2-Minute Neuroscience

Electrical brain stimulation can help recovery from stroke | CTV

Watch the CTV news story.tdcsCtvStrokeStudy

Dr. Alexander Thiel, director of the Comprehensive Stroke Centre at Montreal’s Jewish General Hospital, said the TDCS treatments have been studied before, but what’s special about the study out of Oxford is that it suggests the treatment may be causing structural changes in the brain that contribute to the patient’s recovery.

“This is important because it could either indicate that some parts of these nerve cells are able to regenerate, or these nerve cells try to form alternative pathways  to reroute the traffic in the brain to a different route  from the one that has been destroyed by the stroke,” he told CTV News.

Stroke patients in Canada can’t get TDCS therapy outside of a research study. But with several studies underway around the world, scientists hope they’ll be able to quickly confirm that brain stimulation has the power to accelerate stroke recovery.

Full article: Electrical brain stimulation can help recovery from stroke: study
Study: Ipsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke
Study author: Charlotte Stagg

tDCS Depression Montage

Marom Bikson (no less!) demonstrating depression montage using the Soterix EasyStrap.

From a recent Marom Bikson slide deck.

From a recent Marom Bikson slide deck (pdf).

Prefrontal Electrical Stimulation in Non-depressed Reduces Levels of Reported Negative Affects from Daily Stressors

Prefrontal Electrical Stimulation in Non-depressed Reduces Levels of Reported Negative Affects from Daily Stressors

In two sham-controlled experiments, we found that repeated daily prefrontal tDCS sessions over 5 several days could effectively modulate how non-depressed individuals self-assess their mood states. Results show that participants experienced less psychological distress from daily stressors, a well established cause in the establishment of a negative emotional state. We replicated this finding in an independent, randomized, double-blind experiment applying similar protocol and stimulation on 3 consecutive days.

anode over the left F3 10–20 position, cathode over the contralateral F4 position

anode over the left F3 10–20 position, cathode over the contralateral F4 position

tDCS Boosts Synaptic Plasticity and Memory In Mice via Epigenetic Regulation of Bdnf Expression

Wait! There’s a Science Daily version.
Brain boost: Research to improve memory through electricity?

More important, the researchers identified the actual molecular trigger behind the bolstered memory and plasticity–increased production of BDNF, a protein essential to brain growth. BDNF, which stands for “brain-derived neurotrophic factor,” is synthesized naturally by neurons and is crucial to neuronal development and specialization.

“While the technique and behavioral effects of tDCS are not new,” said ONR Global Associate Director Dr. Monique Beaudoin, “Dr. Grassi’s work is the first to describe BDNF as a mechanism for the behavioral changes that occur after tDCS treatment. This is an exciting and growing research area of great interest to ONR.”

The research is sponsored by the Office of Naval Research!
What he said!

Podda, M. V. et al. Anodal transcranial direct current stimulation boosts synaptic plasticity and memory in mice via epigenetic regulation of Bdnf expression. Sci. Rep. 6, 22180; doi: 10.1038/srep22180 (2016).

I won’t even pretend to understand this paper at this point, but it’s unique enough that I want to encourage people to have a look. That said… what I think it’s saying is that (in mice) hippocampal tDCS creates a chain reaction that results in increased brain plasticity, i.e. increased neuronal connection which in this case is responsible for increased performance in a memory task. (Not more neurotransmitters.)

But this paper suggests the actual mechanism for how this is happening.

We hypothesized that anodal tDCS induced membrane depolarization mimicking neuronal activation and triggered epigenetic changes at Bdnf, thus favoring its transcription.

All together these results indicate that Bdnf expression in the hippocampus is induced by anodal tDCS and that enhanced acetylation at Bdnf promoter I is likely responsible for such effect.

Collectively, these data suggest that anodal tDCS induced epigenetic changes at Bdnf promoters likely relying on a mechanism involving CREB activation, CBP recruitment and H3K9 acetylation.

These results strongly support our hypothesis that increased histone acetylation promoting Bdnf transcription plays a major role in anodal tDCS-induced enhancement of synaptic plasticity.

tDCS-Model of anodal tDCS-induced chromatin remodeling

Halo Neuroscience Launches ‘Halo Sport’

Update 2/29/16. Halo Neuroscience launched the Halo Sport via ProductHunt. Details of the device are discussed in the comment section and includes input from CEO Daniel Chao and CTO Brett Wingeier. In a Medium article industrial designer Matty Martin talks about the challenges developing the Halo Sport. And, though not (yet anyway) peer reviewed, Halo Neuroscience has published the results of a few studies they’ve completed with the Halo Sport. Especially I found interesting Bihemispheric Transcranial Direct Current Stimulation with Halo Neurostimulation System Over Primary Motor Cortex Enhances Fine Motor Skills Learning in a Complex Hand Configuration Task (pdf).

halo-sport

We looked at Halo Neuroscience back in 2012, Halo Neuroscience – Amol Sarva, and knew they’d been testing a device for the last year. Today they announced the release of the Halo Sport which uses ‘neuropriming’ to increase athletic performance. At $549 it’s the most expensive neuro-device to come to market. It seems the target buyer is a high-end athlete.

Clicking on the get button takes you to two offers:

HALO SPORT PRO:
AVAILABLE TODAY
Halo Sport Pro is part of a service package designed for elite teams, trainers, and performance organizations.

and

HALO CHAMPIONS PROGRAM:
LIMITED CONSUMER RELEASE
Train like the pros. Be the first to pre-order Halo Sport and receive $200 off. Ships Fall 2016.

So I guess we’re in buzz-building mode, and the device will become available for anyone in the fall at around $349.

Follows is a clip from today’s Newsweek article. Click through to full story below.

As intriguing as the sports applications are, they only hint at what Halo might become. Chao says he will seek FDA approval to market Halo’s device as a way to help stroke victims recover their physical capabilities. And then, he says, a different version of Halo, which would send pulses into another part of the brain, will be able to improve memory and mental processing, giving users an advantage at work or school. At one point, he tells me some of Halo’s tests show it can “roll back cognitive aging by 25 years.” (He later seems to regret saying that, explaining that he prefers to stay focused on the sports applications.)

Halo Claims to Make You Jump Higher, Think Faster, Remember Longer

tDCS For The Masses – Foc.us ‘Go Flow’

Update 2/29/16 Some details of operation I borrowed from the Foc.us rep on the tDCS subReddit.

Yes, you can do any combination of time and current between the minimum and maximum limits.

The current level can be set from 0.5mA to 2mA, and is indicated with ORANGE lights. Pushing up or down the rocker will change the value in 0.25mA steps. e.g. 0.5, 0.75, 1.0, 1.25, 1.5, 1.75, 2mA.

Once the current is set the lights change to GREEN. This is to set the time and pushing the rocker up or down will change in increments of 5 mins e..g. 5, 10, etc.. to a maximum of 35 mins.

Once you press to confirm the time the session will start. There is a slow ramp-up of current at session start for comfort. The gauge will now change from ORANGE to GREEN every 5 seconds.

During an active session the lights will show you the actual current value or approximate time remaining. Using the same Orange for current and green for duration scales.

If you find the current level too low or too high, you can change it during an active session. Simply press the rocker up or down – but please note the current will be ramped for comfort, so wait for each change to take effect. The lights will instantly change to orange to show you your changed level.

Changing current during active sessions is in 0.125mA steps for fine grained control and accuracy. You can see these hard steps by half lit lights. The current level shown on the ORANGE display is the actual, accurate current.

You can click the rocker during an active session to stop and the current will ramp down and off.

“Does it taper down the current over time, or will it be at a constant current over time?” no, this device will not give you incorrect current, neither too low, nor too high. It will be accurate from start to stop. It will not fail just because you have used the wrong amount of salt or your own choice of electrodes or any of the other things that trip up other devices. If for any reason the device detects it cannot maintain the target current, the LEDs will flash green/orange and the session will be stopped.

At focus we believe that the first job of a current stimulator is to produce an accurate safe current. It is staggering that this is considered optional by other manufacturers.

I think you’ll find its a really simple device to use and operate.
If it flashes orange and green – that means the headset is not connected. If it flashes just orange, that means it cannot reach even 0.5mA. This means the resistance somewhere is too high, usually the pads. Please try with fresh pads and problem should be gone.

Update 1/22/16: Part ll of Brent Williams GoFlow review focuses on choosing electrodes.
Update 1/21/16:  Brent Williams has just published a review of the GoFlow with how-to details The Brain Hacking Revolution Continues: Introducing the foc.us Go Flow – Part 1

Not shipping until March but now taking pre-orders, Now shipping. Foc.us ‘Go Flow’ tDCS device comes in at under $30 including cables and electrodes (hydrogel only for now). But you can purchase the device itself (and use your own electrodes) for less than $15.

Read the ‘Go Flow’ story here: The Story of Focus Go Flow or order one for yourself here: FOCUS Go Flow tDCS Brain Stimulator

20160105focusGoFlow

Nathan Looks At The Braindriver

Nathan, who is our resident expert (and moderator) over at the tDCS Subreddit (you might recall his review of the Focus v2 device) just took a good look at The Braindriver. You can find the full review here.

Thync Announces Sleep Vibe

This is could be a game changer. Announced today on the Thync mailing list. New vibe available for download.

Today, after a full year of clinical sleep studies, we are thrilled to announce a sneak peek of our latest research.20160223thyncSleepAnnounced

After 1 week of using our new Good Night Vibe, our participants reported:

  • Improved sleep quality similar to 4 weeks of meditation or 8 weeks of melatonin
  • Reduced mid-night awakenings
  • Improved morning mood & alertness
  • Reduced anxiety & stress

…And the cherry on top?

The same Good Night Vibe that we used in our clinical testing is now available in the Thync app for you to use!

So go ahead – run your own sleep study: Try out the Good Night Vibe for a week, and let us know what you think!

 

Enhanced Training Through Neurostimulation | HRL Laboratories

What if becoming an expert pilot were as simple as putting on a cap?

That’s the lead-in line on the following video entitled: Enhanced Training Through Neurostimulation presented by HRL Laboratories.  (@HRLLaboratories)

The video is based on the Feb. 9, 2016 study, Transcranial Direct Current Stimulation Modulates Neuronal Activity and Learning in Pilot Training

The researchers featured in the video, post-docs Jaehoon Choe and Matthew Phillips work for HRL Laboratories. Did they know the PR dept. was going to take their interviews and inject them with awesome graphics and all sorts of hyperbole? Is it marketing capitalizing on research, or research capitalizing on marketing?

I plan to dig deeper into this story and update as more info emerges and I get a better understanding of the study.