Although the home use of tDCS is often referred to as a novel phenomenon, in reality the late nineteenth and early twentieth century saw a proliferation of electrical stimulation devices for home use.
In particular, the use of a portable electrotherapy device known as the “medical battery” bears a number of striking similarities to the modern-day use of tDCS.
Many features related to the home use tDCS—a do-it-yourself movement, anti-medical establishment themes, conflicts between lay and professional usage—are a repetition of themes that occurred a century ago with regard to the medical battery.
A number of features seem to be unique to the present, such as the dominant discourse about risk and safety, the division between cranial and non-cranial stimulation, and utilization for cognitive enhancement purposes.
Viewed in historical context, the contemporary use of electrical stimulation at home is not unusual, but rather the latest wave in a series of ongoing attempts by lay individuals to utilize electricity for therapeutic purposes.
Borrowed (screen shot) from the July 2014 Roi Cohen Kadosh edited ‘The Stimulated Brain’ (Google Books link which, though many pages missing, is still full of excellent info or buy it on Amazon,affiliate link).
Click image to open in full size.
An intelligent introduction to tDCS and TMS in the context of Cognitive Enhancement. Dr. Roy Hamilton (at around 19:00 in the video, the beginning is basic intro boilerplate) discusses studies which demonstrate significant positive cognitive effects in healthy individuals. I especially liked Dr. Hamilton’s take on the concerns and potential risks of non-invasive brain stimulation which he discusses towards the end of his talk.
Michael Weisend PHD. is a principal investigator at The Mind Research Network, MRN.org, and assistant professor of Translational Neuroscience at the University of New Mexico, Albuquerque. Dr. Weisend and his team pioneered a method for determining optimal brain regions for tDCS stimulation using fMRI. Much of Dr. Weisend’s work is focused on cognitive enhancement in healthy subjects for the purpose of reducing the amount of time it takes to master a skill. He shared a full hour of his time and a wealth of tDCS-related information. Download the interviewhere (zipped mp3). Subscribe in iTunes. (Firefox users- there’s an issue with the html5 audio player. In the meantime you can download the episode or open the page in another browser).
Just found this in iTunesU. Wow! You’ll recognize many of these names if you’re reading the tDCS literature. I’ve only watched the Michael Weisend talks (whom we met earlier on the blog) so far. I have a much better understanding of the difficulty of running a tDCS trial now. There’s a lot that can go wrong. If your protocols aren’t set up just right, your information might be useless. Here’s the web link iTunes Link from which you can download in iTunes. Downloads are quite slow.
Introduction to Neurosystems Engineering, Spring 2011 (ECE 595) Neurosystems Engineering is an emerging field at the intersection of Neuroscience, Psychology, and Engineering, and the University of New Mexico is its epicenter.
Course Intro Dr. Gerold Yonas
Course Syllabus Dr. Gerold Yonas
Tools and Techniques in Neuronal Stimulation Dr. Edl Schamiloglu
Basic Principles of Feedback and Control Prof. Chaouki T. Abdallah
Discussing the Course General Approach and Direction Dr. Gerold Yonas
Effects of Direct Current, Non-Invasive Brain Stimulation on Learning Michael Weisend
In the Laboratory Transcranial Direct Current Stimulation (tDCS) Michael Weisend
Posttraumatic Stress Disorder: Roles for Treatment & Prevention (Part I) Dr. Pilar M Sanjuan
Posttraumatic Stress Disorder Roles for Treatment & Prevention (Part II) Dr. Pilar M Sanjuan
Tour of the Mind Research Network Dr. Vince D. Calhoun
Neuroimaging of Intelligence and Creativity (Part I) Dr. Rex E. Jung
Neuroimaging of Intelligence and Creativity (Part II) Dr. Rex E. Jung
Memories and Migraines: Application of tDCS Laura Matzen
Neurochemistry Application in NonInvasive Brain Stimulation Dr. Charles Gasparovic
Non-Invasive Brain Stimulation 1:03:47 Lucas C. Parra
Epilepsy, Autism, and Novel Treatment Strategies Dr. Jeffrey David Lewine
The Emerging Field of Sleep Disorders Medicine Dr. Barry Krakow
Presentation of Class Projects Student
Marom Bikson is CEO of Soterix Medical and Associate Professor at City College of New York in the Department of Biomedical Engineering. Marom is a distinguished tDCS scientist and prominent in the development of HD-tDCS. Download the interviewhere (zipped mp3). (Firefox users- there is an audio player here, but it’s displaying intermittently. Trying to track down the issue. In the meantime you can download the episode or open the page in another browser).
(We got a good forty minutes of interview in before the Skype gremlins caught up with us. I had to cobble an ending together.)
Perhaps depression studies are closest to FDA qualification for tDCS?
(Prediction is very hard, especially about the future – Yogi Berra.)
A device (NorDoc Smartstim) that can go to 4mA is being used in a smoking cessation trial? (Trial info indicates 2mA current dose.)
FDA tDCS approval would be device-specific at first. But would open the door to ‘me too’ mechanism, FDA 510(k)
HD tDCS can have multiple cathodes and or multiple anodes. An array of 4 small anodes splitting 2mA, for example (.5 mA each electrode), can function as an anodal ‘virtual pad’. Assumes cathode somewhere else on the body).
Image By Richard McKinley USAF
Tolerability is how tolerable in terms of side effects a medication is.
A Theory of tDCS (“Gross oversimplification”) As positive current flows into the cortex it passes neurons.
Because of the nature of neurons, this positive current depolarizes somas (cell’s body), increasing excitability, thereby increasing the functionality & plasticity of that region (hypothesis… “We really don’t know.”). Under the cathode, somas (cells) are being hyper-polarized – excitabilty decreases.
A synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another cell. Pyramidal neuron
Titration, also known as titrimetry, is a common laboratory method of quantitative chemical analysis that is used to determine the unknown concentration of an identified analyte.
TES Transcranial Electric Stimulation
“transcranial electrical stimulation” Merton and Morton 1980
“Priming the network in conjunction with applying tDCS makes a lot of sense, as a way to make the tDCS to do what you want.” (Co-priming – The idea that one would initiate an activity first, and THEN add tDCS.)